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Week 0
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Week 2
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Week 4
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Week 6
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Week 8
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Week 16
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Week 24
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p
|
|---|
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ALT (iu/L)a
|
25 [20.0,37.3]
|
38 [26.0,53.5]
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39 [26.0,60.0]
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35 [26.0,49.0]
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32 [23.0,41.3]
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24 [19.0,34.3]
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21 [17.0,28.3]
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< 0.0005
|
|
ALT (iu/L)ab
|
41.0 [33.0,62.5]
|
50.0 [40.5,85.0]
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50.5 [39.5,68.3]
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41.0 [34.0,67.3]
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39.0 [32.0,51.0]
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34.5 [25.0,41.3]
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26.5 [21.0,36.5]
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< 0.0005
|
|
ALT normal (iu/L)ac
|
20.5 [17.0,24.0]
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29.5 [20.3,41.0]
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28.5 [20.3,43.0]
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27.0 [21.3,38.5]
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26.0 [18.3,36.0]
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20.0 [17.0,25.0]
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19.0 [16.0,22.0]
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< 0.0005
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Weight (kg)
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144.2 ± 28.0
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137.6 ± 27.4
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134.1 ± 27.0
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131.0 ± 26.2
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128.3 ± 25.6
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123.0 ± 25.0
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121.6 ± 25.4
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< 0.0005
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|
BMI (kg m2)
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50.7 ± 8.1
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47.4 ± 10.4
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45.4 ± 12.0
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44.5 ± 12.0
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45.2 ± 7.6
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43.2 ± 7.5
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43.0 ± 7.6
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< 0.0005
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|
EBW (%)
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103.1 ± 32.4
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89.6 ± 42.0
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81.6 ± 48.2
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78.3 ± 47.4
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81.0 ± 30.6
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73.0 ± 30.0
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71.0 ± 31.0
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< 0.0005
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|
HbA1c (mmol/mol)d
|
39.3 ± 4.0
|
37.6 ± 4.0
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37.0 ± 4.0
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36.3 ± 4.0
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36.0 ± 4.2
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35.4 ± 3.3
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35.3 ± 3.5
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< 0.0005
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|
HbA1c (mmol/mol)e
|
67.2 ± 13.3
|
62.2 ± 13.0
|
59.0 ± 13.0
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56.0 ± 14.2
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54.0 ± 15.0
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48.5 ± 14.4
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48.6 ± 14.1
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< 0.0005
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LDL (mmol/L)
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2.6 ± 1.0
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2.2 ± 1.0
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2.1 ± 0.7
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2.2 ± 1.0
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2.2 ± 1.0
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2.5 ± 1.0
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2.6 ± 1.0
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< 0.0005
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|
HDL (mmol/L)
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1.2 ± 0.4
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1.1 ± 0.3
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1.1 ± 0.3
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1.1 ± 0.3
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1.1 ± 0.3
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1.2 ± 0.3
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1.3 ± 0.4
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< 0.0005
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|
Triglyceride (mmol/L)
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1.8 ± 0.7
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1.5 ± 0.6
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1.4 ± 0.5
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1.4 ± 0.5
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1.3 ± 0.5
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1.3 ± 0.5
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1.3 ± 0.5
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< 0.0005
|
|
Total cholesterol (mmol/L)
|
4.6 ± 1.0
|
3.9 ± 1.0
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3.7 ± 1.0
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3.8 ± 1.0
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4.0 ± 1.0
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4.2 ± 1.0
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4.4 ± 1.0
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< 0.0005
|
- Values are presented as Mean ± SD
- aDenotes variables that are not normally distributed presented as median [IQR]
- bDenotes variables that represent values higher than normal at the start of the programme
- cDenotes variables that represent values that were normal at the start of the programme
- dDenote patients without history of type 2 diabetes
- eDenote patients with history of type 2 diabetes
